Peptide microarrays coupled to machine learning reveal individual epitopes from human antibody responses with neutralizing capabilities against SARS-CoV-2기계 학습과 결합된 펩티드 마이크로어레이는 SARS-CoV-2에 대한 중화 기능을 가진 인간 항체 반응의 개별 에피토프를 나타냅니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] anti-SARS-CoV-2 antibody Antibody binding assays binding epitope capture causative agent cellular coronavirus coronavirus SARS-CoV-2 Course COVID-19 detectable epitope Epitopes human antibody response IgA IgG IgM antibody immunoassays incubated infected with SARS-CoV-2 machine learning Microarray N-terminus negative control samples neutralization neutralization assays Neutralizing Neutralizing antibodies nine overlapping Patient peptide peptide arrays peptides positive protective effect Protective effects random Random forest response S protein SARS CoV SARS CoV-2 SARS-CoV-2 sera serology Serology. Specific structural protein structural proteins the disease the S protein vaccine candidate vaccine candidates Viral [DOI] 10.1080/22221751.2022.2057874 PMC 바로가기 [Article Type] Article
Recombinant Protein Micelles to Block Transduction by SARS-CoV-2 PseudovirusArticle Published on 2022-10-252022-11-16 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Baker block Cell cloned Combination Concentration DAVID Delta delta variant E. coli expressing functional protein Genetic human cells Infection Laboratory micelle Mini-Proteins molecular multifunctional multivalent Multivalent Micelles N-terminus non-toxic Oleosin peptides performed Precision Protein Proteins receptor recombinant Recombinant protein reduced reducing S1 protein SARS-CoV-2 SARS-CoV-2 pseudovirus scattering Seattle Self-Assembly. the SARS-CoV-2 virus the Spike Therapies transduction variant wild-type [DOI] 10.1021/acsnano.2c09015 PMC 바로가기
The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognitionArticle Published on 2022-09-212022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] Affect analysis Analysis Antigen antigen processing Antiviral antiviral activity CD8 Cell Cellular immune response delta variant epitope Ex vivo Express in vitro in vitro result inhibitor Mutation N-terminus neutralizing antibody omicron Protein Replication SARS-CoV-2 SARS-CoV-2 variant suppress susceptibility T cell T cells T-cell target cell TCR the SARS-CoV-2 virus treated variant variants [DOI] 10.1038/s41467-022-33068-4 PMC 바로가기
Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffiiArticle Published on 2022-09-052022-11-16 Journal: Microbial Cell Factories [Category] SARS, 변종, [키워드] addition addressed aggregation Alpha Amino acid applied benefit caused Cell cleavage cleave demonstrated eliminated extension extracellular space functional Golgi highest Host IMPROVE Modification N-terminal N-terminus observation occur peptide Pichia Pichia pastoris product Product quality protease Protein protein engineering protein sequence Proteins purification Receptor binding domain Recombinant protein recombinant proteins residue Saccharomyces cerevisiae secrete secreted secreted protein secretion signal signal peptide signal peptide. steric steric hindrance subunit the SARS-CoV-2 the signal peptide therapeutic vaccine antigen variant variants [DOI] 10.1186/s12934-022-01905-2 PMC 바로가기
Contributions of the N-terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA-induced phase separationArticle Published on 2022-09-012022-11-16 Journal: Protein Science : A Publication of the Protein Soc [Category] SARS, 변종, [키워드] activity acute respiratory syndrome addition affected change coronavirus COVID-19 infections decrease droplet engage Genome genomic RNA host infection induce intrinsically liquid-liquid phase separation modulating molecular Mutation N-terminal N-terminus NMR nucleocapsid protein nucleocapsid protein. omicron phosphorylated post-translational modification Protein Replication RNA RNA concentration SARS-CoV-2 Structural properties the SARS-CoV-2 Transcription undergo variant viral replication virions [DOI] 10.1002/pro.4409 PMC 바로가기
BRET-Based Self-Cleaving Biosensors for SARS-CoV-2 3CLpro Inhibitor DiscoveryArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cells 3C-like protease 3CLpro Activation activity anti-SARS-CoV-2 activities Antiviral biosensor BRET BSL-2 BSL-2 laboratory BSL-3 C-terminus can be used Cell cellular cleavage clinical trial coronavirus diseases COVID-19 COVID-19 treatments decrease drug target embryonic kidney energy transfer evaluate evaluated fluorescent inhibitor inhibitors level 3 linker N-terminus overexpression polyproteins protease Protein released Renilla luciferase reported reproducibility restored resulting SARS-CoV-2 self-cleavage self-cleaving biosensor. sequence small molecule inhibitor treat virus [DOI] 10.1128/spectrum.02559-21 PMC 바로가기
Structural insights into ORF10 recognition by ZYG11BZYG11B에 의한 ORF10 인식에 대한 구조적 통찰력Article Published on 2022-08-062022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 crystal crystal structure Cullin Cullin-RING E3 ligase E3 ubiquitin ligase expand Health Interaction mechanism N-terminal N-terminus ORF10 peptide presenting Protein receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus therapy unique ZYG11B ZYG11B. [DOI] 10.1016/j.bbrc.2022.05.069 PMC 바로가기 [Article Type] Article
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Olverembatinib inhibits SARS-CoV-2-Omicron variant-mediated cytokine release in human peripheral blood mononuclear cellsOlverembatinib은 인간 말초 혈액 단핵 세포에서 SARS-CoV-2-Omicron 변이체 매개 사이토카인 방출을 억제합니다Article Published on 2022-06-082022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] cytokine cytokine release Cytokine storm domain induce Inflammatory inhibit inhibitor kinase signaling. mononuclear cell mononuclear cells Mutation N-terminus NTD Olverembatinib omicron Omicron variant Peripheral blood SARS-CoV-2 Signaling the SARS-CoV-2 variant spike [DOI] 10.15252/emmm.202215919 PMC 바로가기 [Article Type] Article
Development of an Adeno-Associated Virus-Vectored SARS-CoV-2 Vaccine and Its Immunogenicity in Mice아데노 관련 바이러스 벡터화 SARS-CoV-2 백신의 개발 및 마우스에서의 면역원성Article Published on 2022-03-032022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료기술, [키워드] AAV9 adeno-associated virus administration BALB/c mice Cell culture cell culture supernatant development dimeric evaluated expressed expressing Genome HeLa cell HeLa cells immune immunization immunized immunogenicity Intramuscular injection linker long term long term protection mice murine model N-terminus nasal Neutralizing antibodies neutralizing antibody New coronavirus Novel coronavirus outbreak peptide pseudovirus purified Q-PCR RBD Receptor binding domain recombinant RBD protein S protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine sera signal peptide Spike protein the mean the SARS-CoV-2 Vaccine vaccine candidate vaccine. vectored vaccine virus was determined [DOI] 10.3389/fcimb.2022.802147 PMC 바로가기 [Article Type] Article